The snake venom toxin alboaggregin-A activates glycoprotein VI.
نویسندگان
چکیده
The glycoprotein (GP)-Ib-IX-V receptor complex has recently been reported to signal through a pathway similar to that used by the collagen receptor GPVI, with a critical role described for the Fc receptor gamma-chain. The evidence for this was based in part on studies with the GPIbalpha-selective snake venom toxin, alboaggregin-A. In the present study, it is reported that alboaggregin-A has activity at the collagen receptor GPVI in addition to GPIbalpha, and evidence is provided that this contributes to protein tyrosine phosphorylation, shape change, and GPIIb-IIIa-dependent aggregation. This may explain why responses to alboaggregin-A are distinct from those to von Willebrand factor-ristocetin. (Blood. 2001;97:3989-3991)
منابع مشابه
Brief report The snake venom toxin alboaggregin-A activates glycoprotein VI
The glycoprotein (GP)–Ib-IX-V receptor complex has recently been reported to signal through a pathway similar to that used by the collagen receptor GPVI, with a critical role described for the Fc receptor g-chain. The evidence for this was based in part on studies with the GPIbaselective snake venom toxin, alboaggregin-A. In the present study, it is reported that alboaggregin-A has activity at ...
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عنوان ژورنال:
- Blood
دوره 97 12 شماره
صفحات -
تاریخ انتشار 2001